卡贝缩宫素在预防产后出血的疗效观察

Effects of cabernet oxytocin in prevention of postpartum hemorrhage

目的观察卡贝缩宫素预防产后出血的疗效。方法将600例在我院分娩的产妇随机分为观察组和对照组各300例。观察组胎儿前肩娩出后立即注射卡贝缩官素100μg。对照组胎儿前肩娩出后立即舌下含服前列甲酯栓（卡孕栓）1．0mg，对比分析两组产程中、产后2h、产后24h出血量及不良反应情况。结果观察组产程中、产后2h、产后24h出血量分别为：（150．1±42．3）ml，（118．6±36．2）ml，（46．0±14．2）m1；对照组产程中、产后2h、产后24h出血量分别为：（166．3±40．5）ml，（135．1±37．7）ml，（108．5±21．2）ml。观察组出血量明显少于对照组，差异均有统计学意义（均P〈0．05），两组产程中出血量差异无统计学意义（P〉0．05）。结论卡贝缩宫素预防产后出血起效快、效果持久，无不良反应，可明显减少产后出血，值得临床推广应用。

Objective To observe the effects of cabernet oxytocin in prevention of postpartum hemo]Thage. Methods 600 expectant mothers were randomly divided into 2 equal groups： observation group uundergoing venous injection of cabernet oxytocin 100 txg immediately after the delivery of the fore shoulder, and control group undergoing sublingual administration of methyl carhoprost suppository 1.0 mg immediately after the delivery of the fore shoulder. The amounts of blood loss and adverse outcomes were observed during the birth process, and 2 h and 24 after the delivery. Results The 2 h and 24 h postpartum hemorrhage amounts of the observation group were （150.1± 42.3）, （118.6±36.2） ml and （46.0± 14.2） ml respectively, both significantly lower than those of the control group （166.3 ±40.5）, （135.1±37.7） ml and （108.5±21.2） ml respectively, both P〈0.05. Adverse reactions were mild and there were not significant differences in adverse reactions between these 2 groups （all P〉0.05）. Conclusion Without severe adverse reaction, cabernet oxytocin has a rapid onset and long duration, significantly reduces the postpartum hemorrhage, and is worthy to be recommended clinically.