用药监控在围术期抗菌药物应用中的作用

Perioperative medication monitoring rational use of antimicrobial agents

目的探讨用药监控在围手术期抗菌药物应用中的作用。方法回顾性分析我院自2007年6月～2009年6月间用药监控前各科应用抗菌药物病历164份和2009年7月～2011年6月间用药监控后各科应用抗菌药物病历153份,调查分析和比较两个时间段术前围手术期抗菌药物的监测情况。结果 1)实施用药监控后,三、四代头孢菌素和加酶抑制剂品种减少,选用一、二代头孢菌素的病例较前显著增加;2)用药前细菌学检查率低,多数采用经验用药;3)两组术后切口和院内感染的发生率差异无统计学意义(P>0.05)。结论用药监控可以提高围手术期抗菌药物使用的合理性。

Objective To investigate drug monitoring in the perioperative period in the role of antimicrobial agents.Methods A retrospective analysis of our hospital from June 2007～ June 2009 drug control between the application of antibiotics before the medical records of 164 subjects were,and in June 2009～July 2011 drug control between the application of antibiotics after the subjects medical records 153,for two periods of preoperative prophylactic use of antimicrobial drug,antimicrobial drug use prior to bacteriological monitoring of the situation,incision,or nosocomial infection and drug selection and so reasonable investigation,analysis and comparison.Results 1）The implementation of drug control,the third and fourth generation cephalosporin antimicrobial and enzyme inhibitors reduce the variety,selection of a second-generation cephalosporin antimicrobial increased significantly compared with the previous cases;2）Low bacteriological examination before treatment,most experience of drug use;③ Postoperative incision and the incidence of nosocomial infection was no significant difference（P〉0.05）.Conclusions The drug monitoring can improve the perioperative rational use of antibiotics.