摘要
目的探讨对氧磷酶2(PON2)基因311Cys/Ser(C/S)基因多态性及血脂血糖指标与海南地区阿尔茨海默病(AD)的关系。方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术对22例AD患者和31例年龄匹配的健康对照者进行PON2-311Cys/Ser基因多态性及血脂血糖指标的分析。结果 AD患者组PON2-311基因频率和等位基因频率与健康对照组之间比较无显著性差异。总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)和血糖(Glu)在老年性痴呆症患者和健康对照者间无显著性差异(P>0.05)。SS基因型人群中低密度脂蛋白(LDL-C)在老年性痴呆症患者和健康对照者间有显著性差异(P<0.05)。结论海南地区PON2基因C311S多态性及血脂血糖指标与AD患者没有显著相关性。
Objective To study the relationship between paraoxonase-2（PON2） gene 311Cys/Ser（C/ S） polymorphism with blood lipids and blood glucose index and Alzheimer＇s disease（AD） in Hainan. Methods Paraoxonase-2 311 Cys/Ser gene polymorphism and blood lipids and blood glucose for 22AD patients and 31 age-matched health controls were analysised by using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Results The gene frequencies and allele frequencies of the paraoxonase-2 311Cys/Ser in AD were not significantly different from those of control. The levels of total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol（HDL-C）, apolipoprotein A（Apo A）, apolipoprotein B（Apo B） and blood glucose（Glu） were no significant difference in the case and control group（P〉 0.05）. In the SS genotype, low density lipoprotein cholesterol（LDL-C） was different between the case and control group （P〈0.05）. Conclusion The polymorphism of PON2 C311S gene and blood lipids and blood glucose were not significant associated with AD in Hainan.
出处
《分子诊断与治疗杂志》
2012年第4期253-257,共5页
Journal of Molecular Diagnostics and Therapy
