摘要
目的探讨血胱抑素C(Cys-C)、白细胞介素6(IL-6)水平检测对诊断糖尿病早期肾功能损害的意义。方法按尿微量清蛋白(UmAlb)将糖尿病患者分为2组,A组为UmAlb<30mg/d,单纯DM组,56例;B组为UmAlb30～300mg/d,早期DN组,58例;同时设健康对照组50例;测定各组Cys-C、Scr、IL-6水平。结果糖尿病患者Cys-C、Scr、IL-6水平均高于对照组(P<0.05),B组Cys-C、IL-6水平高于A组(P<0.05);糖尿病B组Cys-C、IL-6水平异常检测率明显高于Scr水平。结论 Cys-C、IL-6是早期诊断糖尿病肾损害的敏感指标之一。
Objective To explore the diagnostic significance of serum Cystatin C （Cys-C） and IL-6 detection in the early stage renal damage in diabetes. Methods According to the level of urinary microalbuminuria（UmAlb） ,diabetic patients were divided into 2 groups. 56 cases （A group） of patient with simple diabetes mellitus（UmAlb〈30mg/d） ; 58 cases （B group） of pa- tients with early diabetic nephropathy;while 50 healthy persons （C group） without diabetes. Serum creatinine, Cys-C and IL-6 were measured in each group, Results In patients with diabetes,Cys-C and IL-6 on average were higher than that in patients without diabetes （P〈0.05）,and higher in B group than that in A group （P〈0.05）. In B group, the positive rates of Cys-C and IL-6 were significantly higher than those of Scr （P〈0.05）. Conclusion Cys-C and IL-6 are the sensitive indicators to diagnosis early stage clinical diabetic nethropathy.
出处
《中国现代医药杂志》
2012年第7期48-50,共3页
Modern Medicine Journal of China
