摘要
β内酰胺类/β内酰胺酶抑制剂复方制剂是治疗产β内酰胺酶耐药菌感染的药物之一。β内酰胺类药物的T>MIC用于确定给药方法、给药剂量,预测药物临床治疗效果。其与β内酰胺酶抑制剂组成的复方抗菌药物,仍是时间依赖性抗菌药物;复方制剂的抗菌药需T>MIC超过给药间隔的40%~50%。需注意复方制剂两组分间的药代动力学应具备良好的同步性。
β-lactam/β-lactamase inhibitor compound preparation is used for treatment of β-lactamase-producing resistant bacterias.In the research and use of the β-lactam/β-lactamase inhibitor compound preparation,in addition to simply take into account to overcome the bacteria producing β-lactamases esistance mechanisms,should be considered with the β-lactam/β-lactamase inhibitor pharmacokinetics/pharmacodynamics(PK/PD) interrelated issues.For the β-lactam antibiotics,T〉MIC is the main PK/PD parameters,used to determine the administration method,dosage,prediction of clinical drug treatment,and β-lactamase inhibitor compound consisting of antimicrobial agents still time-dependent antimicrobial agents,enzyme inhibitors is to enhance the antibacterial drug activity does not play an antibacterial effect,compound preparations that need to antimicrobial agents T〉MIC delivery interval of more than 40% to 50%.Because of the special compound,should be noted between the two components of compound preparations pharmacokinetics whether they have a good synchronization.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第7期543-546,共4页
The Chinese Journal of Clinical Pharmacology