代谢组学技术在神经精神性疾病中的应用研究进展

Progress of metabolomics in the neuropsychiatric diseases

神经精神性疾病的发病过程,一般与氧化应激、神经递质和脂肪酸代谢紊乱及线粒体功能异常有关。代谢组学技术则能通过分析比较不同病理生理状态下体内小分子代谢产物,全面监测多条与疾病相关的代谢通路,进而寻找有价值的生物标志物,揭示其病理过程。本文主要对代谢组学技术在精神分裂症、抑郁症、帕金森等神经精神性疾病中的应用进行了综述。

Neuropsychiatric diseases are linked to disturbances in metabolic pathways related to neurotransmitters,fatty acids,oxidative stress and mitochondrial function.Though cataloguing of the small molecular metabolites that existed in any particular organism and maping in greater detail perturbations in many biochemical pathways,metabolomics enable us to find the disease-specific biomarkers and pathological mechanism.In this review,recent advances in metabolomics are briefly introduced.We also highlight recent findings from metabolomic studies in CNS diseases such as schizophrenia,depression,Parkinson’s disease,et al.