用供体腹主动脉行肝动脉重建小型猪肝移植模型的可行性研究

Pig model of liver transplantation with the hepatic artery reconstruction by the donor's aorta

目的探讨用供体腹主动脉行肝动脉重建小型猪肝移植模型的可行性。方法取广西巴马小型猪10头(供、受体各5头),在取供体时,切取与腹腔动脉相连的一段腹主动脉,在供肝植入时用该段腹主动脉与受体腹主动脉吻合进行肝动脉重建,以获得植入肝理想的人肝血流。结果 5例受体巴马小型猪肝血流再通后在胆管吻合前均见金黄色胆汁流出,受体猪术后24 h均存活,手术获得成功。结论在巴马小型猪的肝移植术中使用供体腹主动脉进行肝动脉重建是可行的,研究结果为使用供体腹主动脉进行肝动脉重建的肝移植动物实验研究提供了重要基础。

Objective To investigate the feasibility of pig model of liver transplantation with the hepatic ar- tery reconstruction by the donor＇ s aorta. Methods Ten miniature pigs were chosen, 5 pigs as donor, the other 5 pigs as recipient. The part of the aorta with the artery system of the donor was kept when retrieval of donor liver and the artery anastomosis by the donor＇ s aorta to the recipient aorta was performed when liver transplantation. Results The liver transplantation of the all 5 cases was successful. The normal yellow bile was seen before the anastomosis of bile duct and 5 cases pigs were alive 24 hours after the operation. Conclusion The feasibility of pig model of liver transplantation with the artery anastomosis by the donor＇ s aorta to the recipient aorta was confirmed and the study is a good base for deeper study of the research of liver transplantation with the artery anastomosis by the donor＇ s aorta to the recipient aorta.