毛细血管渗漏综合征临床研究进展

Clinical research progress of capillary leak syndrome

毛细血管渗漏综合征(capillary leak syndrome,CLS)是危重患者常见的一组临床综合征。其病情危重且病理生理复杂,CLS临床表现为进行性全身水肿、低血压、低氧血症、低蛋白血症、少尿等,CLS的发生常常有明确诱因,主要有严重感染、严重创伤、中毒等。其诊断主要根据临床表现与实验室检查。治疗方法主要是保证有效血容量、保证组织氧供、治疗原发病和改善毛细血管通透性等。了解其发病机制并予正确治疗方法,CLS是可以逆转的。该文就其病因、发病机制、诊断及治疗方面的研究进展情况作一简要的综述。

Capillary leak syndrome （CLS） is a group of clinical syndromes in critical patients. The patient＇ s condition is serious and the CLS＇ changes in pathophy is complicated. The clinical manifestations of CLS include sys- temic edema,low blood pressure, hyoxemia, hypoproteinemia, oliguria and so on. The occurrence of CLS often has a difinite incentive cause,including severe infection, severe trauma, poisoning and so on. The diagnosis of CLS is based mainly on clinical manifestation and laboratory examination. The treatments include controlling primary disease, liquid treatment, and improving the capillary permeabilety and so on. Understanding CLS＇ pathogenesis and giving the right treatment will be useful in the reversal of CLS. In this paper, the clinical research progress on the cause, pathogenesis, diagnosis and treatment of CLS is briefly reviewed.