动态荧光分子成像技术研究进展

Progress in dynamic fluorescence molecular imaging

动态荧光分子成像技术能够描述荧光分子探针在生物体内吸收、分布以及排出的完整过程,是一种可以对生物体的生理、病理过程进行连续监测的动态成像技术.这项技术具有无电离辐射、成像速度快、灵敏度及特异度高、费用低廉等优点,在基础医学及临床医学研究中具有广阔的应用前景.从系统、算法和应用3个方面对动态荧光分子成像技术的研究进展进行了综述.

Dynamic fluorescence molecular imaging is a kind of technique that can capture the dynamic physiology and pathology process in vivo by imaging the whole progress of absorption, distribution and elimination of fluorescence molecular probes in small animals. It has the advantages of non-ionizing radiation, fast imaging, high sensitivity and specificity, low cost, and has broad application prospects in basic and clinic medical research. This paper reviews the research progress in dynamic fluorescence molecular imaging from three aspects including system, algorithm and application.