中枢神经细胞瘤的临床病理观察

Histopathological analysis of central neurocytoma

目的探讨中枢神经细胞瘤(CNC)的临床病理特点、肿瘤发生、诊断和鉴别诊断,提高对此瘤的认识,避免误诊。方法对2例原发脑室、额叶内的CNC进行光镜观察,应用突触素(Syn)、神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)等进行免疫组织化学染色分析其本质,并复习文献。结果 2例肿瘤1例发生于侧脑室,1例发生于额叶。组织学特点:肿瘤由密集一致的小圆形细胞组成,胞质透明,有核周空晕,核小而圆,居中,呈菊形团状排列,特征性改变为无核神经元纤维基质岛。免疫组织化学显示Syn、NSE阳性。结论 CNC是伴神经元分化的肿瘤,免疫组织化学对确诊CNC很重要。

Objective To study the histopathological characteristics,tumorigenesis and differential diagnosis of central neurocytoma（CNC） for avoiding its misdiagnosis.Methods Histopathological characteristics of CNC were retrospectively studied by Syn,NSE,GFAP etc..Results Two cases of tumor located in the ventricle or in the frontal lobe respectively.Histologically,two cases were composed of small uniform round cells.These tumor cells were arranged in rosettes pattern and had a centrally located small and round nucleus,showing clear cytoplasm and perinuclear halo.The most dominant feature of CNC was the matrix island composed of neurofibrill.Tumor cells of CNC demonstrated positive for Syn and NSE.Conclusions CNC is associated with neuronal differentiation,immunohistochemistry is very important for the diagnosis of CNC.