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不同胎龄新生儿成骨细胞标志物的研究

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摘要 目的:通过比较不同胎龄新生儿血清骨钙蛋白及骨碱性磷酸酶水平,了解不同胎龄新生儿成骨细胞的功能状况。方法:以不同胎龄的90例新生儿为研究对象,根据胎龄分为三组,<32周胎龄组,32~36周胎龄组,37~42周胎龄组,生后6 h内采集空腹静脉血2 ml,分离血清,单克隆抗体酶联免疫法测定骨碱性磷酸酶含量。结果:①<32周胎龄组,32~36周胎龄组,37~42周胎龄组三组血清骨钙蛋白水平分别为(23.04±11.57)μg/L、(30.33±10.43)μg/L、(33.43±11.02)μg/L。<32周胎龄组与32~36周胎龄组、37~42周胎龄组差异均有统计学意义(P<0.05);32~36周胎龄组和37~42周胎龄组差异无统计学意义(P>0.05)。②<32周胎龄组,32~36周胎龄组,37~42周胎龄组三组血清骨碱性磷酸酶水平分别为(123.51±17.43)μg/L、(72.03±17.99)μg/L、(71.63±20.72)μg/L。<32周胎龄组与32~36周胎龄组、37~42周胎龄组差异均有统计学意义(P<0.05);32~36周胎龄组和37~42周胎龄组差异无统计学意义(P>0.05)。结论:胎龄32周以后出生的新生儿其骨骼生长发育基本接近正常足月儿,而32周以前出生的新生儿其骨骼生长发育不成熟。
作者 张艳玲
出处 《中国妇幼保健》 CAS 北大核心 2012年第22期3430-3431,共2页 Maternal and Child Health Care of China
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参考文献4

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