西宁地区儿童甲型H1N1流感血清抗体水平调查

Investigation on the level of serum influenza A antibody in children in Xining

目的:了解流行期西宁地区儿童甲型H1N1流感病毒抗体水平的变化趋势和特点。方法:在青海省儿童医院随机选择就诊儿童747例,采集静脉血进行甲型H1N1流感血清抗体水平检测和分析。结果:调查期间儿童总体阳性率为42.97%,GMT水平为1∶23.92。疫苗接种人群的阳性率和GMT水平为93.75%和1∶54.33,明显高于未接种疫苗人群的36.88%和1∶19.83。非疫苗免疫儿童中,9～岁、12～岁年龄组抗体阳性率和GMT水平最高,0～岁年龄组最低,并且随年龄增长呈增高趋势(P<0.01)。结论:经过流行期后,西宁地区儿童已经形成一定的保护屏障,但婴幼儿保护性抗体比例仍然较低,提示该人群是今后甲型H1N1流感重点保护的对象。

Objective： To understand the change trend and characteristics of influenza A （H1N1） antibody level in children in Xining during epidemic period. Methods： A total of 747 children who were treated in Qinghai children＇s hospital were selected randomly, then venous blood specimens were collected to detect and analyze the serum level of H1N1 antibody. Results： Among the children investiga- ted, the total positive rate of H1 N1 antibody was 42. 97%, the level of GMT was 1 ： 23.92, The positive rate of I-I1 N1 antibody and GMT lev- el in the population receiving vaccine inoculation were 93.75% and 1： 54. 33 . respectively, which were significantly higher than those in the population without vaccine inoculation （36. 88% and 1： 19.83, respectively） . Among the children without vaccine planned immunization, the positive rate of H1 N1 antibody and GMT level in 9 - age group and 12 - age group were the highest, while the positive rate of H1 N1 an- tibody and GMT level in 0 - age group was the lowest, showing an increasing trend with age （P 〈 0.01 ） . Conclusion： The children in Xining had a certain protective barrier after epidemic period, but the proportion of infants with protective antibody was still low. Which indi- cates that the infants were the key protection objects against H1N1.