2010年洛阳地区手足口病重症病例的流行病学特征

Epidemiological characteristics of severe cases with hand-foot-mouth disease in Luoyang in 2010

目的:了解洛阳地区2010年重症手足口病(HFMD)的流行病学特征。方法:对2010年河南科技大学第一附属医院收治的801例重症HFMD患儿进行人口学、生长发育、生活、地理环境以及大便中EV71、CoxA16和其他肠道病毒核酸进行调查。结果:2010年洛阳地区重症HFMD总发病率为12.5/10万,64.67%是1～3岁(不含)幼儿,85.52%是散居儿童,84.82%为EV71病毒感染。男童发病率高于女童。92.13%分布在平原地区,71.16%居住在农村。38.83%的患儿BMI<P15。7月是发病高峰时期。结论:2010年洛阳地区重症HFMD以EV71感染为主;发展经济、提高全民素质、改善卫生环境是降低重症HFMD患病率的主要措施。

Objective ： To understand the epidemiological characteristics of severe cases with hand - foot - mouth disease （HFMD） in Luoyang in 2010. Methods： The demographic characteristics, growth and development, living environment, geographical environment, nucleic acids of enterovirus 71 （ EV71 ）, coxsaekie virus A16 （ CoxA16 ） , and other enteroviruses in stool specimens of 801 severe HFMD children who were treated in the hospital in 2010 were investigated. Results： The total incidence of severe HFMD in children in Luoyang in 2010 was 12. 5/100 000, 64. 67% of them were infants aged 1 - 3 years old, 85.52% of them were scattered children, 84. 82% of them were infected by EVT1. The incidence of severe HFMD in boys was higher than that in girls. Among the children, 92. 13% of them were dis- tributed in flat area, and 71.16% of them were distributed in rural area. BMI of 8.83% of the children was less than P15. July was a season with peak incidence of HFMD in children. Conclusion： EV71 is the main virus of severe HFMD in children in Luoyang in 2010; the key measures to reduce the incidence of severe HFMD in children include developing economics, improving the quality of population, and impro- ving hygienic conditions.