日常性体力活动与绝经后骨质疏松症发病风险的关联性

Association between habitual physical activity and onset of postmenopausal osteoporosis

目的:探讨日常性体力活动与绝经后骨质疏松症(PMOP)发病风险的关联度。方法:1∶1配比的病例-对照研究。采用《国际体力活动问卷》(IPAQ)对67例PMOP患者(病例组)和67例健康体检人员(对照组)目前体力活动水平进行调查。将总体体力活动水平分为体力不足、体力活跃和高度活跃;将职业性、交通行程性、家务劳动和休闲性体力活动水平分为单项体力不足和体力活跃。采用条件Logistic回归方法,以OR值和95%CI表示体力活动水平与绝经后骨质疏松症发病风险的关联程度。结果:病例组和对照组之间总的体力活动水平、交通行程性、休闲性体力活动水平比较差异有统计学意义(P<0.01)。病例组总体体力不足者比例高于对照组(20.9%vs 6.0%);而体力活动水平达到高度活跃的比例低于对照组(35.8%vs 67.2%)。交通行程性体力活动可以降低PMOP的发病风险(OR=0.223,95%CI:0.058～0.856);职业性、家务性体力活动在病例组和对照组之间比较差异无统计学意义(P>0.05)。锻炼方式中,步行或慢跑可能是防治PMOP的有效途径(OR=0.064,95%CI:0.007～0.563)。结论:包括体育锻炼在内的负重性体力活动可能有助于降低PMOP的发病风险。

Objective To investigate the association between habitual physical activity and onset of postmenopausal osteoporosis（PMOP）.Methods The hospital-based case-control study included 67 cases of PMOP（case group） and 67 healthy women（control group）.The women verbally answered the International Physical Activity Questionnaire for assessment of physical activity levels.This instrument evaluated the frequency and duration of activities performed during transportation,at work,at home or in leisure time-over the course of recent one year.The risk of disease was represented by using odds ratio and 95% confidence interval.Results The physical activities in total and transportation,leisure-time were different between case group and control group（P〈 0.01）.The physical activities in occupational,housework did not show significant difference between case group and control group（P〉0.05）.The physical activity in transportation significantly decreased the risk of PMOP（OR=0.223,95% CI：0.058-0.856）.The results demonstrated that moderate walking exercise in postmenopausal women appeared to be effective way to decrease the risk of PMOP（OR=0.064,95%CI：0.007-0.563）.Conclusion The weight-bearing physical activities including weight-bearing physical exercise can be likely to decrease PMOP risk.