硝苯地平联合卡托普利治疗原发性高血压的疗效研究

Efficacy of nifedipine combined with captopril in treatment of essential hypertension

目的研究硝苯地平联合卡托普利治疗原发性高血压的疗效。方法收集本院收治的原发性高血压患者临床资料,在给予硝苯地平联合卡托普利治疗后,监测患者的血压、蛋白尿以及高血压引起的心绞痛缓解情况。结果用药后,2组平均血压值均发生明显下降,治疗组疗效明显好于对照组。对照组心绞痛的缓解情况明显好于治疗组,而治疗组治疗后24 h尿蛋白明显下降,低于对照组。结论硝苯地平和卡托普利对于原发性高血压有较好疗效,总体有效率达到95%,尤其对于伴有蛋白尿的高血压患者能够显著改善蛋白尿的状况。

Objective To study the efficacy of nifedipine combined with captopril in treat- ment of essential hypertension. Methods The clinical data of patients with essential hypertension in our hospital were collected. After administration of nifedipine combined with captopril, improve- ment of patient＇ s blood pressure, proteinuria, and hypertension - induced angina pectoris were monitored. Results After treatment, the mean blood pressure values of both groups were signifi- cantly decreased. The therapeutic effect was significantly better in the treatment group than in the control group. The remission of angina pectoris was much better in the control group than in the treatment group. After treatment, 24 h urinary protein decreased more significantly in the treat- ment group than in the control group. Conclusion Nifedipine and captopril has a good effect on essential hypertension disease with an overall response rate of 95 %. It can significantly improve the status of proteinuria of patients with hypertension accompanied by proteinuria.