咳嗽变异性哮喘过敏原检测分析

Detection and analysis of allergen in patients with cough variant asthma

目的探讨咳嗽变异性哮喘(CVA)与过敏原之间的相互关系,为CVA的临床诊治提供依据。方法应用Mediwiss公司出品的AllergyScreen过敏原检测系统对58例CVA患者、51名非CAV型慢性咳嗽患者进行过敏原体外免疫测试,并计算各种过敏的所占阳性比例。结果 1种以上过敏原阳性率,CVA组为81.03%(47/58),非CAV组为19.61%(10/51),两组相比,差异有高度统计学意义(P<0.01);而其中4种过敏原的阳性检出率两组之间的差异均有统计学意义(P<0.05)。结论 CVA与过敏因素关系密切;可用过敏原体外检测辅助诊断咳嗽病因。

Objective To study the correlation between cough variant asthma （CVA） and allergens to provide basis for the clinical diagnosis and treatment of CVA. Methods The allergen detection system, made by AllergyScreen of Mediwiss company, was employed to detect in vitro al- lergen in 58 CVA patients and 51 non- CAV patients with chronic cough and the positivity ratios of various allergens were calculated in the two groups. Results The positivity rate of more than one allergen in the CVA group was 81.03% （47/58）, which was notably higher than the 19.61% in the non-CAV group（10/51） （P〈0.01）. The positivity rates of four kinds of allergens between the two groups showed statistically significant differences （P 〈 0.05）. Conclusion CVA and aller- gic factors are closely related to each other. In vitro allergen detection can assist in identifying causes of cough.