选择性动脉化疗栓塞在晚期贲门癌中的临床应用

Clinical application of selective artery chemoembolization for advanced gastric cardia cancer

目的探讨选择性动脉化疗栓塞在晚期贲门癌中的临床应用价值。方法对20例晚期贲门癌患者行选择性动脉化疗栓塞治疗,并进行分析。结果本组所有20例患者术后2个月有效率(RR)为65.0%,疾病控制率(DCR)为95.0%。KPS评分改善、稳定和下降者分别为15、4、1例,改善率+稳定率为:95.0%(19/20)。血清CEA、CA199表达水平术后1、2个月较术前明显降低,差异均有统计学意义(P<0.05)。术后均出现不同程度恶心、呕吐、上腹胀痛、低热等症状,经对症治疗后好转,无严重并发症发生。结论选择性动脉化疗栓塞能够明显改善晚期贲门癌患者的临床症状,减轻患者痛苦,提高生活质量,并有效延长患者生存期,值得临床上推广应用。

Objective To investigate the clinical application of selective arterial chemoembolization in patients with advanced gastric cardia cancer.Methods Twenty patients with advanced gastric cardia cancer received selective arterial chemoembolization and the clinical data were analyzed.Results The response rate and disease control rate were 65.0% and 95.0% respectively 2 months after operation in all 20 patients of this group.Fifteen patients had KPS score improved,4 stabilized and 1 decreased.The improvement rate,together with the stability rate was 95.0%（19/20）.Serum CEA and CA199 expression levels 1 or 2 months after operation were significantly lower,and the differences were statistically significantly（P〈0.05）.All patients had symptoms of nausea,vomiting,abdominal pain and fever.Improvement was observed after treatment with no serious complications.Conclusion Selective arterial chemoembolization can significantly improve the clinical symptoms of advanced gastric cardia cancer patients,reduce their sufferings,improve their quality of life,and prolong their survival period.Thus it is worthy of clinical application.