氨氯地平和依那普利对合并高血压的糖尿病患者肾脏保护的比较

Comparison of protective effects of amlodipine and enalapril on renal functions of patients with diabetic hypertension

目的观察氨氯地平和依那普利对合并高血压的糖尿病患者血压及尿白蛋白排泄率(UAER)的影响。方法随机将55例合并高血压的糖尿病患者分为2组:氨氯地平组和依那普利组。疗程52周,观察治疗前后血压及UAER的变化。结果两组治疗后均能明显降低血压及UAER,但两组比较,UAER差异无显著性(P>0.05)。结论氨氯地平和依那普利均能有效降低血压,并减少尿蛋白的排泄,保护肾脏功能。

Objective To observe the effect of amlodipine and enalapril on the blood pressure and urinary albumin excretion rate（UAER） of patients with diabetic hypertension.Methods A total of 55 patients were randomly divided into amlodipine group and enalapril group.The treatment cycle was 52 weeks.The changes of blood pressure and UAER were recorded before and after treatment.Results Blood pressure and UAER decreased significantly in both groups after treatment.No significant UAER difference was found between the two groups（P〉0.05）.Conclusion Both amlodipine and enalapril can effectively decrease blood pressure,reduce UAER and protect renal function.