缬沙坦对原发性高血压合并糖尿病患者血压及肾功能影响的研究

Influence of valsartan on blood pressure and renal function in patients with essential hypertension complicated with diabetes

目的探讨缬沙坦在原发性高血压合并糖尿病治疗中的作用。方法原发性高血压合并糖尿病患者40例随机分为治疗组(20例)和对照组(20例)。治疗组口服雷米普利联合缬沙坦;对照组口服雷米普利,2组均治疗24周。观察2组治疗后的降压疗效、24 h尿蛋白、血尿素氮(BUN)、血肌酐(SCr)等指标的变化情况。结果治疗组降压总有效率为75.0%,高于对照组降压总有效率(70.0%),但差异无统计学意义(P>0.05)。2组治疗后24 h尿蛋白水平均较治疗前明显降低,治疗组降低水平较对照组更加明显。结论缬沙坦治疗原发性高血压合并糖尿病安全有效,更有利于保护肾脏功能。

Objective To investigate the role of valsartan in the treatment of primary hypertension complicated with diabetes.Methods Forty patients with essential hypertension complicated with diabetes were randomly divided into treatment group（n=20） and control group（n=20）.The treatment group was administered ramipril combined with valsartan while the control group only ramipril.Both groups were treated for 24 weeks.After treatment,the changes of the antihypertensive efficacy,24 h urinary protein,blood urea nitrogen（BUN）,and serum creatinine（SCr） in both groups were observed.Results The overall antihypertensive efficacy rate（75.0%） was higher in the treatment group than that（70.0%）in the control group,but the difference was not statistically significant（P〉0.05）.After treatment,24 h urinary protein level was significantly lower in both groups.But compared with the control group,the treatment group had more significant decrease.Conclusion The valsartan treatment for hypertension complicated with diabetes is safe and effective.It can better protect renal function.