重组人表皮生长因子凝胶在浅Ⅱ度烧伤创面护理中的应用

Application of recombinant epidermal growth factor gel on the nursing of superficial 2nd burn wound

目的观察重组人表皮生长因子凝胶在浅Ⅱ度烧伤创面护理中的应用效果。方法选择50例浅Ⅱ度烧伤患者，采用同体对照法，将同一创面不同区域或同体对称部位的创面分为观察组和对照组。观察组采用重组人表皮生长因子凝胶加医用硅酮凝胶膏混合后湿敷创面；对照组采用医用硅酮凝胶膏湿敷创面。观察两组创面愈合时间、换药次数、疼痛状况及渗液情况的差异。结果观察组的创面平均愈合时间（8．6±1．6）d较对照组（11．8±1．7）d明显缩短，差异有统计学意义（t=-9．834，P〈0．05）。观察组换药次数（4．5±0．9）次较对照组（6．1-I-0．9）次明显减少，差异有统计学意义（t=-9．336，P〈0．05）。两组患者的换药疼痛程度相似，差异无统计学意义（x^2=0．272，P〉0．05）。两组在第2次换药时的渗液程度相似，差异无统计学意义（x^2=0．205，P〉0．05）；而在第3和4次换药时，观察组渗液程度较对照组明显改善，差异有统计学意义（x2分别为8．988，5．316；P〈0．05）。结论重组人表皮生长因子凝胶能减少浅Ⅱ度烧伤创面的渗液量，减少换药次数，可明显促进表皮生长，加速创面愈合。

Objective To observe the therapeutic effect of recombinant epidermal growth factor gel on the nursing of superficial 2nd burn wound. Methods Totals of 50 patients with superficial 2nd burn were selected. By means of auto-control, different region of the same wound or symmetrical wounds were divided into observation group and control group. In the observation group, recombinant epidermal growth factor gel was mixed with silicone gel cream and was covered the wound humidly. The control group adopted silicone gel cream only to humidly covered wounds. Wound healing time, dressing change frequency, pain intensity and level of exudates in two groups were observed and analyzed. Results Average wound healing time in control group was （ 11.8±1.7 ） days and （8.6±1.6） days in observational group, and the difference was statistically significant （ t = - 9. 834, P 〈 0.05 ）. Dressing frequencies in the observational group and control group respectively was （4.5±0.9） and （6.1±0.9） times, and the difference was statistically significant （ t = - 9. 336, P 〈 0.05 ）. There was no significantly difference in the intensity of dressing pain,and the degree of exudates of 2nd time of dressing was detected between control group and observation group （P 〉 0.05）. While in the 3rd and 4th time of dressing, degree of exudates of observational group was significantly improved than that of the control group （ X^2 = 8. 988,5.316 respectively; P 〈 0.05 ）. Conclusions Recombinant epidermal growth factor application can decrease exudates level and dressing changing frequency, and significantly improve epidermal regeneration so as to accelerate wound healing.