手术治疗原发性食管小细胞癌疗效分析

Clinical analysis of primary small cell carcinoma of esophagus undergone surgical treatment

目的分析手术治疗原发性食管小细胞癌的疗效。方法选择我院2004年8月至2006年6月26例行手术治疗的食管小细胞癌患者,所有患者均随访1～5年,对手术治疗后的效果,患者1、3、5年生存率进行观察。结果 26例食管小细胞癌患者后术后TNM分期Ⅰ期1、3、5年生存率分别为100%(6/6),66.67%(4/6),33.33%(2/6)。TNM分期Ⅱ期1、3、5年生存率分别为42.86%(6/14),7.14%(1/14),0(0/14)。TNM分期Ⅲ期生存率分别为33.33%(2/6),0(0/14),0(0/14)。患者死亡原因均为肿瘤转移至肝、肺等部位。结论原发性食管小细胞癌预后极差,外科手术是治疗I、Ⅱ期病例的主要治疗手段,术后化疗可提高疗效;对于Ⅲ、Ⅳ期病例,则应以化疗和放疗为主要治疗手段。

Objective To analyse the curative effect of surgical treatment for primary. small-cell esopha-goal carcinoma （PSEC）. Methods Retrospective analysis was made on the 26 cases of pathologically testified PESCC undergone surgical treatment that were collected during the ＇period of August 2004 to June 2006. Results According to the New TNM Classification in Esophageal Carcinoma ,within the 28 eases underg- one surgical treatment,The 1-year,3-year and 5-year survival rate of the cases in stage TNM I were 100% （6/ 6） ,66.67% （4/6） ,33.33% （2/6） ,and the cases in stage TNM II were 42. 86% （6/14） ,7. 14% （1/14） ,0 （0/14） ,and the cases in stage TNM Ⅲ were 33.33% （2/6） ,0（0/14） ,0（0/14）. The causes of death in pa- tients with tumor metastasis to the liver, both lung and other parts. Conclusion PSEC is a rare malignant tumor with poor prognosis. Surgical operation is the treatment majo of the cases in stage TNM Ⅰ, Ⅱ , postoperative chemotherapy can improve the efficacy. The main therapeutic method of the TNM Ⅲ, Ⅳ cases is chemotherapy and radiotherapy