摘要
目的:观察奥麦特林联合迪恩安治疗慢性乙肝的临床效果。方法:将61例慢性乙肝患者随机分为治疗组32例及对照组29例,均给予迪恩安肌注、口服益肝灵和肌苷片,但治疗组同时加服奥麦特林,疗程均6个月;观察症状、肝功、乙肝病毒血清学指标、HBV-DNA。结果:疗程结束ALT、TBIL复常率治疗组90.6%和93.8%显著高于对照组69%(P<0.01);治疗组HBsAg、HBeAg、HBV-DNA转阴率及抗HBe转阳率分为21.9%、56.3%、62.5%、53%;与对照组10.3%、37.9%、44.8%、34.5%比差异显著(P<0.01);对照组发生6例血小板减少、4例白细胞减少。结论:奥麦特林多环节、多途径治疗乙肝,联合干扰素具有明显协同作用,且升高白细胞及血小板,降低干扰素对外周血象的不良影响,是安全、良效、价廉的乙肝药。
Objective： to observe Oxymatrine soft capsule for the treatment of chronic hepatitis B,joint＂ Di en an＂ of clinical effect. Methods ：61 cases of chronic hepatitis B patients were randomly divided into the treatment group 32 patients and control group 29 patients,all give＂ Di en an＂ muscle note, ora Silymarin and both inosine liver piece, but the meanwhile treatment group Add oral administration Oxymatrine soft capsule, period of treatment all are june;Observation of symptoms, liver meritorious service is, second liver virus serological index, HBV - DNA. Results：treatment end ALT and TBIL after return to normal rate treatment group 93.8% and 90.6% in control group was significantly higher than 69% （ P 〈 0.01 ） ; The treatment group HBsAg, HBeAg, HBV -DNA turn Yin rate and resistance to turn into HBe Yang rate 21.9%, 56. 3%, 62. 5% and 53%;And the control groupl0. 3% ,37.9% ,44.8% ,34.5% than the significant difference （ P 〈 0.01 ） ; The control group 6 cases happened thrombocytopenia, 4cases leukopenia. Conclusion： Oxymatrine soft capsule many link, many approach to treat second liver, coalition interferon has obvious synergy, and increase the white cell and the platelets, reduce the interferon foreign weeks the bad influence of blood picture is safety,fine effect,low price of second liver medicine.
