血中甲状腺素和脑钠肽在新生儿缺血缺氧性脑病诊断和预后判断中的价值评价

The Effect of Thyroxine and Brain Natriuretic peptide on Diagnosis and Prognosis of Children with Hypoxic Ischemic Encephalopathy

目的观察血中甲状腺素和脑钠肽在新生儿缺血缺氧性脑病(HIE)诊断和预后判断中的价值。方法 90例HIE患儿分为轻度42例,中度27例,重度21例,选30例正常新生儿为对照组。分别测定血中甲状腺素和脑钠肽,并跟踪6月观察发育商数。结果与对照组比较,HIE组FT3、FT4明显降低,在HIE三组之间有明显差异;脑钠肽明显升高,在HIE三组之间有明显差异;DST正常组FT3、FT4和脑钠肽与可疑/异常组比较有明显差异。结论甲状腺素和脑钠肽生化指标,可提示新生儿HIE的发生,并能反映其严重程度,并且对新生儿HIE预后可能有预测作用。

Objective To study the effect of thyroxine and brain natriuretic peptide（BNP） on diagnosis and prognosis of children with hypoxic ischemic encephalopathy（HiE）.Methods 90 children with HIE were divided into mild group（n=42 cases）,moderate group（n=27 cases） and severe group（n=21 cases）.30 normal newborn were enrolled. Thyroxic and BNP were detected. The developmental quotient of infants was followed for 6 months. Results Compared with the control group, FT3 and FT4 were decreased and BNP was increased. There were significant differences between three groups with HIE. There were significant differences between normal group with DST and suspicious/unusual group. Conclusions Thyroxic and BNP could prompt the severity and prognosis.