纤维蛋白原不同检测方法结果的分析

Aanalysis of fibrinogen detection results with methods

目的:用凝血酶原衍生法(PT-Der)、Von Clauss法检测纤维蛋白原,观察两者的差异性及相关性。方法:采用Sysmex CA7000全自动血凝仪及配套试剂分别用PT-Der法和Von Clauss法检测328例患者的血浆纤维蛋白原水平。结果:当Fg含量在2.00 g/L～4.00 g/L范围内时,PT-Der法和Von Clauss法检测结果无显著差异(P>0.05),相关良好(r=0.957);而当Fg<2 g/L或Fg>4 g/L时,两种方法存在显著差异(P<0.05),相关性也降低。结论:Fg含量在正常参考范围内时,可用PT-Der法检测纤维蛋白原,对于超出范围者,须用Von Clauss法再次检测。

Objective：To investigate the difference and relationship between prothrombin derivative（PT-Der） method and Von Clauss method in detecting fibrinogen.Methods： Plasma fibrinogen levels of 328 patients were detected with PT-Der method and Von Clauss method on Sysmex CA7000 automatic coagulation analyzer respectively.Results： Fibrinogen levels measured with PT-Der method and Von Clauss method showed no significant difference（P0.05） and correlated well between 2 g/L and 4 g/L.However,fibrinogen results differed significantly between the two methods（P0.05） when Fg2 g/L or Fg4 g/L.Conclusin： PT-Der method can be used to detect fibrinogen,but results should be verified by Von Clauss method when the fibrinogen concentration were out of the normal reference.