宁波市2010年-2011年重症手足口病病原学及流行特征分析

Analysis of etiology and epidemiology characteristics of severe Hand-foot-and-mouth disease in Ningbo in 2010 and 2011

目的:了解宁波市手足口病重症病例的病原学类型,为本地区手足口病的综合防制提供参考资料。方法:收集2010年-2011年医院临床诊断为手足口病重症病例的粪便标本,应用RT-PCR技术检测肠道病毒通用型(EV)、肠道病毒71型(EV71)、柯萨奇病毒A组16型(CoxA16)。结果:171例手足口病重症病例中,EV71型病毒占81.28%,CoxA16型病毒占1.75%,其他肠道病毒占16.96%;5月-7月为高发月份,1岁组重症病例最多,重症病例人群男性高于女性(1.76∶1)。结论:EV71型是宁波地区手足口病重症病例的主要致病病毒类型,其流行具有明显的年龄、季节界限。

Objective：To learn the etiological characteristics of severe hand-foot-and-mouth disease（HFMD） in Ningbo,so as to provide evidence for the prevention and management policy of this disease.Methods： Fecal specimens were collected from patients who were diagnosed as severe HFMD in 2010 and 2011.RT-PCR was employed to detect general enterovirus,EV71 and CoxA16 in these specimens.Results： The proportion of EV71,CoxA16 and other enterovirus were 81.28%,1.75% and 16.96% in 171 severe HFMD cases;The high-occurrence months were from May to July.Most severe cases were found in 1-year-old group.Male severe cases were more than female cases（1.76∶ 1）.Conclusion： EV71were the major pathogens of severe HFMD in Ningbo,and the prevalence had obvious age and season limit.