FA值在急性缺血性脑梗塞诊断中的临床应用

Clinical Application of MRI-FA Value for the Acute Cerebral Infarction Diagnosis

目的:探讨不同时期(<72h、8～14d)脑梗塞患者梗死侧病变FA值及对应正常脑组织FA值,旨在分析FA值性急性脑梗死的临床价值。方法:收集2011年1月～2012年1月于新疆医科大学第二附属医院神经内科明确诊断为急性缺血性脑梗死的患者34例,男性19例,女性15例,年龄35～73岁,平均年龄58±2.4岁。对所有患者在急性期(发病时间<72h)行1.5T常规头颅MRI检查DTI及DTT检查,测量梗死灶和对侧相应正常脑组织的部分各向异性值(FA值)、表面扩散系数(ADC值),皮质脊髓束(corticospinal tract,CST)与梗死灶的关系分为相邻、部分穿过及完全穿过三组,来分析FA的变化及其与病程时间的关系。结果:分析不同病程中脑梗死侧与相对应健侧的FA值及ADC值,结果显示急性期梗死灶白质的FA值及ADC值均比对侧正常白质的FA值和ADC值降低;同时,梗死灶FA值下降率与发病时间存在相关关系,即急性期梗死灶FA值的下降率与发病时间呈正相关关系,具有统计学意义(P<0.05);结论:急性期梗死灶白质FA值及ADC值均比对侧正常白质的FA值和ADC值降低;同时,梗死灶FA值下降率与病程时间存正相关关系。

Objective： TO explore the different period （ than 72 hours a day,8 - 14） in patients with cer-ebral infarction lateral lesion of the decretion ratio of FA and the corresponding normal brain tissue the decrc-tion ratio of FA, aimed at the analysis of the decretion ratio of FA of acute cerebral infarction provide clinical references for the disease. Methods： All the patients were collected from department of Neurology of the Sec-ond Affiliated Hospital of Xinjiang Medical University from January 2011 to January 2012, totally 34 patients, including 19 males and 15 females, aged 35-73 years, mean 58 ±2.4 years. All patients in the acute phase （onset time 〈72h） did 1.5T conventional MRI examination DTI and DTr, measure the FA and ADC values of infarct and corresponding part of the contralateral normal brain tissue, Three patterns of CST involvement were identified according to the relation of the corticospinal tract （CST） and infarct： close, partly involved and completely involved, to analyse the FA changes and disease duration time relationship. Result： Compared with corresponding part of the contralateral normal brain tissue, the decretion ratio of FA and ADC values of white matter in infarct region of acute ischemic cerebral infarction patients decreased and the decretion ratio of FA was positively correlated with the onset time, it had statistical significance （,P 〈 0.05） Conclusion： Com-pared with corresponding part of the contralateral normal brain tissue, the FA and ADC values of white matter in infarct region of acute ischemic cerebral infarction patients decreased and the decretion ratio of FA reduction was positively correlated with the onset time.