早发型重度子痫前期并发低蛋白血症的临床分析

Clinical Analysis of Early Onset of Severe Preeclampsia Complicated With Hypoalbuminemia

目的:探讨低蛋白血症对早发型重度子痫前期妊娠结局的影响。方法:对98例早发型重度子痫前期患者的临床资料进行分析总结,按是否发生低蛋白血症分为低蛋白血症组和非低蛋白血症组,对其一般资料、并发症、胎儿新生儿情况进行比较。结果:早发型重度子痫前期患者合并低蛋白血症,两组治疗时间、终止妊娠孕周、入院时平均动脉血压等指标比较,差异均有统计学意义(P<0.05),低蛋白血症组发生肝肾功能损害、胸腹水、胎盘早剥、心功能不全的发生率均高于非低蛋白血症组,差异有统计学意义。在低蛋白血症组将24h尿蛋白定量与血浆白蛋白值比较,两者间无相关性(r=-0.026,P=0.114)。低蛋白血症组围生儿死亡率明显增加(P=0.000),新生儿窒息率也存在差异(P=0.037);两组血浆白蛋白值与新生儿体重呈正相关性.结论:并发低蛋白血症是重度子痫前期病情的进一步加重,可能出现严重并发症,并可造成围生儿不良结局。

Objective： To investigate the effect of hypoproteinemia on prenatal outcomes of pregnant women with early onset of severe preeclampsia. Methods： 98cases of early onset severe pre - eclampsia pa-tients clinical data were analyzed, then case group was divided into hypoproteinemia group and non - hypopro-teinemia group . to compare the effect of difference among the two groups on the general data, complications, fetal neonatal comparison. Results ： compared with two groups, the differences of the treatment duration, ter- mination of pregnancy, gestational age at admission and mean arterial blood pressure , were statistically signif- icant （P 〈 0.05 ）, hypoalb ascites, placental abruption uminemia groups occurred in liver and kidney function damage , heart failure rates are higher than the hypoproteinemia group, , hydrothorax and the difference was statistically significant. 24h quantity of urinary protein and plasma albumin values of the hypoproteinemia group is no correlation （ r = 0. 026, P = 0.114）. prenatal mortality rate of hypoproteinemia group increased significantly （ P = 0）, the rate of neonatal asphyxia differences （ P = 0.037 ） ; two groups of plasma albumin values and neonatal weight positively correlated. Conclusion ： Early onset of severe preeclampsia patients com-plicated with hypoalbuminemia prompted further aggravate the disease, may appear serious complication, and can be the cause of prenatal adverse outcomes.