原发性高血压患者中血管紧张素转换酶2基因单核苷酸多态性与缬沙坦降压疗效的相关性研究

Relationship between the angiotensin converting enzyme 2 gene polymorphism and antihypertensive effect of valsartan

目的探讨原发性高血压患者中血管紧张素转换酶2基因单核苷酸多态性与原发性高血压发生及缬沙坦治疗的疗效关系。方法应用直接测序方法对120例原发性高血压和60例正常人群中血管紧张素转换酶2（ACE2）基因作SNP分型。结果男、女原发性高血压患者G8790A位点上G等位基因频率和正常人群中相比有统计学意义（X2=5．310，4．423，P〈0．05）；其与用药前、后血压的变化无统计学意义（P〉0．05）。结论血管紧张素转换酶2基因的A1675G单核苷酸多态性与原发性高血压发病有关，携带G等位基因人群发生高血压的危险性相对较大，ACE2可作为原发性高血压的候选易感基因。

Objective To study the relationship of single nucleotide polymorphism of angiotensin converting enzyme 2 （ACE2 ） with essential hypertension（EH） and antihypertensive response of valsartan. Methods A total of 120 case EH patients was received valsartan once daily for four weeks. Direct DNA se- quencing was performed to detect the signgle nucleotide polymorphisms of ACE2 in 120 EH patients and 60 controls with normal blood pressure. Results The genotyping data indicated that there were significant differences of G allele frequency between male or female E H group and controls （X2 = 5.310,4. 423, P 〈 0.05 ）. Treated with valsartan, patients with G allele were not found to be associated with reduction in blood pressure（ P 〉 0. 05）. Conclusions Our data suggest that the ACE2 G8790A signgle nueleofide polymor- phisms might be involved in the development of EH. The risk developing hypertension in the people carry- ing G allele is higher than that in those carrying other allele. Therefore, ACE2 gene might be a sensitive gene associated with EH.