摘要
目的:研究偏侧咀嚼对大鼠颞下颌关节(TMJ)滑膜血管内皮细胞生长因子(VEGF)表达的影响。方法:30只大白鼠随机分为6组,实验组间断磨除右侧上、下颌磨牙牙冠至龈下,对照组未做处理,饲养条件相同。实验1组磨除牙冠后4周末、实验2、3组磨除牙冠后10、16周末处死动物,取其双侧TMJ切片免疫组化检测。结果:实验1、2、3组双侧颞下颌关节滑膜VEGF表达较对照组增强。结论:偏侧咀嚼可引起颞下颌关节滑膜损伤,VEGF参与了其病理过程。
Objective： To study the expressions of VEGF in temporomandibular joint synovial membrane in rats with unilateral Chewing, and to discuss the mechanism of temporomandibular disorders. Method： 30 white rats were divided into three experiment groups and three control groups. The right upper and lower posterion teeth of all the experiment groups were ground to the gingival level without occlusal contact. The rats of the first experiment and control groups were killed 4 weeks late, and those of the second and third groups were killed 10.16 weeks late respectively. The section of TMJ synovial membrane underwent the immunohistological study. Result：The expressions of VEGF in temporomandibular joint synovial membrane in the experiment groups were higher than that control groups. Conclusion：The unilateral chew can cause the damage in temporomandibular joint synovial membrane and VEGF might participate in the histopathologic mechanism of tem- poromandibular joint disorders.
出处
《临床口腔医学杂志》
2012年第8期489-491,共3页
Journal of Clinical Stomatology
基金
山东省科学技术发展计划项目资助(2011GGH21822)
