^(18)F-FDG和^(18)F-FLT PET显像SUV在肺结块诊断中的价值

The value of SUV in ^(18)F-FDG and ^(18)F-FLT PET imaging for diagnosing pulmonary nodules

目的:探讨18F-氟氏脱氧葡萄糖(18F-FDG)和18F-氟氏胸腺嘧啶(18F-FLT)PET显像诊断肺结块的影响因素,以提高PET/CT对肺结块的诊断价值。方法:选择肺结块患者55例为研究对象,其中28例为肺内孤立结块,其余为2～3个结块,结块大小0.6～11.0cm。所有患者均行肺部18 F-FDG和18 F-FLT PET/CT检查,检查结果按不同性别、年龄、结块大小及病理类型进行分组,以各组18F-FDG和18F-FLT显像标准摄取值(SUV)的均数为界定标准,分析SUV与肺结块患者的性别、年龄、结块大小及病理类型等相互关系。结果:55例肺结块患者,不同性别、年龄、结块大小患者的18 F-FDG和18F-FLT显像SUV差异均无统计学意义(P>0.05),不同病理类型患者的18 F-FDG显像SUV差异无统计学意义(P>0.05),而不同病理类型患者的18F-FLT显像SUV差异有统计学意义(P<0.05)。结论:肺结块患者结块的病理类型是影响18F-FLT显像SUV的重要因素,18F-FLT PET/CT显像SUV鉴别诊断肺结块良恶性具有重要的价值和意义。

Objective：The study aims to investigate the diagnostic performance of dual-tracer 18F- fluorodeoxyglucose （18 F-FDG） and 18 F-fluorothymidine （18 F-FLT） PET/CT in pulmonary nodules, to differentiate the malignant tissue from benign pulmonary nodules. Methods： To choose 55 patients with pulmonary nodules as study target. In all cases, 28 cases were pulmonary nodules alone,others were 2 or 3 pulmonary nodules,and the sizes were 0.6- 11.0 cm. 18 F-FDG and 18 F- FLT PET/CT were performed in 55 patients. The groups of results were showed with sex, age, size and pathology of all pulmonary nodule patients, the define standard was according to SUV of every group on average. To study the affect of SUV of 18 F-FDG and 18 F-FLT with all groups. Results： There were no significant differences between the SUV of 18F FDG and sex, age, diameter of the nodule, type of the pathologic nature of nodule of all fifty-five patients （P〉0.05）, however, there were significant differences between the SUV of 18FFLT and the type of pathologic nature of nodules of all fifty-five pa- tients （P〈0.05）. Conclusion： The study showed that 18 F-FLT PET/CT SUV can accurately differentiate carcinoma from benign nodules.