摘要
目的:研究益母草Leonurus japonicus果实茺蔚子中的化学成分。方法:茺蔚子乙酸乙酯部位经硅胶,RP-18,Sephadex LH-20和HPLC等色谱技术分离纯化,根据理化常数和波谱数据鉴定化合物的结构。结果:分离鉴定了2个具有特殊骨架的28位去甲基齐墩果烷型螺环三萜。结论:化合物1为新化合物,命名为茺蔚子三萜A(leonujaponin A),化合物2为已知化合物,鉴定为phlomistetraol B,均为首次从益母草属植物中分离得到。
Objective： To study the chemical constituents from the fruits of Leonurus japonicus. Method： The compounds were extracted by 70% methanol, then isolated and purified by column chromatography on silica gel, RP-18, Sephedax LH-20 and HPLC. Their structures were determined on the basis of spectroscopic data and physicochemical property. Result： Two 28-noroleanane-derived spirocyclic triterpenoids including a new acylated nortriterpenoid were isolated and identified as （17R）-19 （18→17）-abeo-2a, 18β,23- trihydroxy-3fl-E-feruloyoxy-28-norolean-12-ene （1） and phlomistetraol B （2）. Conclusion： Compound 1 is a new compound, named as leonujaponin A. Both compounds 1-2 are isolated for the first time from Leonurus plants.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第14期2088-2091,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(U1032602,91013002,30725048)
国家自然科学基金-云南联合基金项目(U1032602)
国家“重大新药创制”科技重大专项(2011ZX09307-002-02)
国家重点基础研究发展计划(973)项目(2009CB522300)
