摘要
目的:测定Graves病和2型糖尿病患者血清中与胰岛素抵抗(IR)相关的因子视黄醇结合蛋白(RBP)-4和白细胞介素(IL)-6水平,探讨Groves病患者发生IR的机制。方法:107例Graves病患者根据甲状腺功能水平分为Graves病初诊组54例、Graves病治疗组53例,2型糖尿病组53例,选择同期健康查体者50例作为对照组。抽取各组清晨空腹肘正中静脉血5mL,测定空腹血糖、胰岛素水平、计算胰岛素抵抗指数,酶联免疫吸附测定(ELISA)法检测血清RBP-4和IL-6的水平,并结合临床指标进行分析。结果:2型糖尿病组空腹血糖高于其他3组,FINS和HOMA-IR水平在2型糖尿病组最高,对照组最低,RBP-4的水平在Graves病初诊组、Graves病治疗组和2型糖尿病组高于对照组(均P<0.01)。IL-6的水平在Graves病初诊组高于Graves病治疗组、2型糖尿病组和对照组(均P<0.01)。结论:RBP-4和IL-6可能在Graves病IR的发病过程中有一定作用。
Objective： To investigate the serum concentrations of retinol binding protein （RBP）-4 and interleukin-6 （IL-6） in patients with Graves disease and type 2 diabetes. Methods： One hundred and seven patients with Graves disease were divided into initial diagnosis group （n=54）, treatment group （n=53） and type 2 diabetes group （n=53）. Fifty healthy sub- jects were selected for the control. The levels of glucose and insulin were detected using fasting blood samples. The serum lev- els of RBP-4 and IL-6 were detected by enzyme-linked immunosorbent assay （ELISA）. Results： The serum levels of RBP-4 were significantly higher in initial diagnosis group, treatment group and type 2 diabetes group than those of control group（P 〈 0.01）. The serum levels of IL-6 were significantly higher in initial diagnosis group than those of treatment group, type 2 diabe- tes group and control group （P 〈 0.0l）. Conclusion： The serum levels of RBP-4 or IL-6 may play a role in the pathogenesis of Graves disease.
出处
《天津医药》
CAS
北大核心
2012年第8期769-771,共3页
Tianjin Medical Journal
