黏附分子L1在胃肠道间质瘤中的表达及其临床意义

Expression and Clinical Significance of Adhesion Molecule L1 in Gastrointestinal Stromal Tumors

目的:探讨黏附分子L1在胃肠道间质瘤(GIST)中的表达情况及其临床意义。方法:采用免疫组织化学法和RT-PCR检测66例GIST、10例平滑肌肿瘤、6例神经鞘瘤及14例正常肠壁组织中L1的表达情况,并分析其临床意义。结果:胃肠道间质瘤中L1蛋白及mRNA的表达率分别为57.6%(38/66)和83.3%(30/36),差异有统计学意义(P<0.05);L1在不同侵袭危险性GIST中的表达差异有统计学意义(P<0.05),但在不同性别、年龄、肿瘤部位、组织学类型中的表达差异无统计学意义(P>0.05)。L1在GIST中的表达明显高于其在平滑肌肿瘤及正常肠组织中的表达(P<0.01),与其在神经鞘瘤中的表达差异无统计学意义(P>0.05)。结论:L1表达在GIST发生发展过程中起促进作用,L1可作为GIST的诊断和鉴别诊断指标。

Objective： To investigate the expression of the adhesion molecule L1 in gastrointestinal stromal tumors （GIST）, and the clinical significance thereof. Methods： The expression leyels of L1 were detected in tissues of 66 samples of GIST, 10 samples of smooth muscle tumors, 6 samples of schwannoma and 14 samples of normal bowel by immunohistochem- istry and RT-PCR, and their clinical significances were analyzed~ Results： The expression rates of L1 protein and mRNA in GIST were 57.6% （38/66） and 83.3% （30/36）, which were significantly different between two groups （P 〈 0.05）. The L1 expres- sion was significantly different in the different aggressive risk of GIST （P 〈 0.05）, but there was no significant difference in dif- ferent age, gender, tumor locus and tissue type groups （P 〉 0.05）. The expression of L1 was significantly higher in GIST than that of smooth muscle tumor and normal bowel tissues （P 〈 0.01）. There was no significant difference in the expression of L1 between GIST group and schwannoma groupss （P 〉 0.05）. Conclusion： The expression of L1 may play an important role in tu- morigenesis and progression of GIST, which suggest that L1 can be applied to diagnosis or differential diagnosis of GIST.