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工作场所空气中异氰酸甲酯的高效液相色谱测定法 被引量:1

Determination of methyl isocyanate (MIC) in air of workplaces by HPLC
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摘要 目的建立工作场所空气中异氰酸甲酯(MIC)的高效液相色谱测定方法。方法空气中蒸气态的MIC用浸渍过l-2-吡啶基哌嗪(1-2PP)的XAD-7管采集,MIC与荧光衍生剂1-2PP反应,在XAD.7管上生成稳定的荧光化合物,用乙腈解吸,经色谱柱分离,荧光检测器检测。结果该法在0.01-10μg/ml范围内呈线性关系,检出限为5.3×10^-4μg/ml;定量下限为O.01μg/ml;最低检出浓度为3.3×10^-3mg/m^3(以采集3L空气样品计),相对标准偏差为2.2%-5.3%,平均解吸效率为90%,采样效率为100%,样品在冷藏状态下(5℃)能保存10d。结论方法各项指标均符合GBZFF210.4-2008(职业卫生标准制定指南第4部分:工作场所空气中化学物质测定方法》的要求,适用于工作场所空气中蒸气态异氰酸甲酯的检测。 Objective To establish the method of detecting the concentrations of methyl isocyanate (MIC) in air ofworkplaces with high performance liquid chromatographic (HPLC). Methods Samples are collected by XAD-7 tubes coated with l-(2-pyridyl) piperazine (1-2PP). Samples are desorbed with acetonitrile (ACN) and analyzed by high performance liquid chromatography (HPLC) using a fluorescence detector. Results There was a linear relationship within the range of 0.01×10μg/ml, and the detection limit was 5.3×10-4μg/ml.The minimum detectable concentration was 0.01μg/ml, and the lowest detected concentration was 3.3×10-3 mg/m3. The relative standard deviation was 2.2%-5.3%. The average desorption efficiency was 90% and the sampling effieiencies were 100%. The samples could be stored for 10 days in cold storage condition. Conclusion The present method could meet with the requirements of Guide for establishing occupational health standards-Part 4 Determination methods of air chemicals in workplace and be feasible for determination of MIC in workplace air.
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2012年第8期618-620,共3页 Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词 MIC 空气 工作场所 高效液相色谱法 MIC, Workplace air, High performance liquid chromatography
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  • 1国家环境保护局,《空气和废气监测分析方法》编写组.空气和废气监测分析方法[M]中国环境科学出版社,1990.
  • 2李述文,范如霖.实用有机化学手册[M]上海科学技术出版社,1981.

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