摘要
1例60岁男性患者肾癌术后自行口服索拉非尼0.2 g、2次/d。2个月后患者出现全身乏力伴巩膜黄染、尿黄。实验室检查:总胆红素(TBil)146μmol/L,直接胆红素(DBil)94μmol/L,丙氨酸转氨酶(ALT)959 U/L,天冬氨酸转氨酶(AST)1150 U/L,γ-L-谷氨酰转肽酶(γ-GT)507 U/L。停用索拉非尼,给予三磷酸胞苷二钠、还原型谷胱甘肽、腺苷蛋氨酸治疗。24 d后复查肝功能:TBil 19μmol/L,DBil 10μmol/L,ALT 54 U/L,AST 40 U/L,γ-GT 22 U/L。
A 60-year-old male patient self-medicated with oral sorafenib 0.2 g twice daily after renal cancer surgery.After two months of treatment,he presented with generalized weakness,scleral jaundice and dark urine.Laboratory tests revealed the following levels: total bilirubin(TBil) 146 μmol/L,direct bilirubin(DBil) 94 μmol/L,alanine aminotransferase(ALT) 959 U/L,aspartate aminotransferase(AST) 1150 U/L and gamma-glutamyltransferase(γ-GT) 507 U/L.Sorafenib was stopped and he was given cytidine disodium triphosphate,reduced glutathione and ademetionine.Twenty-four days later,repeat liver function tests revealed the following levels: TBil 19 μmol/L,DBil 10 μmol/L,ALT 54 U/L,AST 40 U/L,γ-GT 22 U/L.
出处
《药物不良反应杂志》
2012年第3期168-169,共2页
Adverse Drug Reactions Journal
关键词
肝炎
药物性
索拉非尼
hepatitis,drug-induced
sorafenib
