摘要
1例64岁男性患者因甲状腺功能亢进症接受甲巯咪唑(10 mg,2次/d口服)和普萘洛尔(10 mg,3次/d口服)治疗。5 d后患者出现皮疹伴瘙痒,自行服用氯雷他定后症状好转。第25天甲巯咪唑剂量调整为10 mg,3次/d口服;普萘洛尔调整为20 mg,3次/d口服,并行保肝治疗。调整剂量后第9天患者出现间歇性、游走性关节疼痛和关节活动受限,第11天停用甲巯咪唑并给予美洛昔康。停用甲巯咪唑后2周患者关节疼痛明显好转,无关节活动受限。
A 64-year-old male patient received thiamazole （ 10 mg two times every day orally ） and propranolol （ 10 mg three times every day orally ） for hyperthyroidism. Five days later, the patient developed skin rash with itching which improved after self- taking loratadine. On day 25, dosages of thiamazole and propranolol were adjusted to 10 mg three times daily and 20 mg three times daily, respectively, and he received hepatoprotective treatment as well. On day 9 after adjusting the dosages, the patient developed intermittent and migratory joint pain and limited joint mobility. On day 11, thiamazole was stopped and meloxicam was given. Two weeks after thiamazole discontinuation, his joint pain significantly improved without limited joint mobility.
出处
《药物不良反应杂志》
2012年第3期176-177,共2页
Adverse Drug Reactions Journal
