隐匿性乳腺癌62例临床分析

Occult breast cancer, report of 62 cases

目的分析隐匿性乳腺癌的临床特征及预后影响因素。方法回顾性分析天津市肿瘤医院1997年10月至2011年10月收治的62例隐匿性乳腺癌的临床病理资料，对其临床特征及影响预后的因素进行分析。结果62例隐匿性乳腺癌患者3、5、10年总生存率分别为87．4％、76．4％、73．2％；中位生存期为53个月。阳性淋巴结数目〉4个的患者3、5、10年总生存率低于阳性淋巴结数目≤4个者（77．8％、64．8％、38．9％比90．7％、86．7％、86．7％，P=0．015）。乳腺癌根治术后病理切片发现原发灶组3、5、10年总生存率低于未发现原发灶组（60．O％、40．0％、40．0％比92．0％、83．6％、79．2％，P=0．023）。有复发转移组总生存率低于无复发转移组（63．5％、28．6％、19．O％比97．1％、97．1％、97．1％，P=0．000）。结论隐匿性乳腺癌预后与阳性淋巴结数、乳腺病理切片能否发现原发灶以及有无复发转移有关。

Objective To analyze the clinical ieatures and prognostic tactors of occult breast cancer. Methods The clinical features and prognostic factors of 62 occuh breast cancer patients, who were treated in Tianjin Cancer Hospital from October 1997 to October 2011, were retrospectively analyzed. Results The 3-year, 5-year and 10-year overall survival rates of 62 cases were 87.4% ,76.4% ,73.2% respectively,a median of 53 months. The 3-, 5-, and 10-year overall survival rates of the patients with 〉4 positive lymph nodes are lower than that of patients with ~〈4 nodes （77. 8% ,64. 8% ,38.9% vs. 90. 7%, 86.7% ,86.7%, P = 0. 015 ） ; The 3-year and 5-year overall survival rates of patients with primary cancer found in removed breast tissue are lower than that in those primary tumor was not found （60.0% ,40. 0%, 40.0% vs. 92. 0% ,83.6% ,79. 2% , P =0. 023）. The 3-year, 5-year and 10-year overall survival rates in patients with recurrence and metastasis are lower than that of patients without （63.5% ,28.6% ,19.0% vs. 97.1% ,97. 1% ,97.1%, P = 0. 000）. Conclusions The prognosis of occult breast cancer is related with the number of positive lymph node, pathology, recurrence and metastasis.