精神发育迟滞患者的PET脑代谢显像

PET observation of cerebral metabolism in mental retardation patients

目的观测精神发育迟滞(MR)患者的脑代谢变化。方法对32例临床确诊MR患者行18 F-FDG PET脑显像,目视观察18F-FDG PET脑代谢显像中的葡萄糖代谢分布变化状况,分析患者智商低下与PET、磁共振和脑电图等表现的关系。结果 32例MR患者中,19例(19/32,59.38%)PET脑显像异常,均为放射性分布减低,受累部位包括额叶6例(6/19,31.58%)、颞叶15例(15/19,78.95%)、顶叶12例(12/19,63.16%)、枕叶和小脑共4例(4/19,21.05%),其中13例(13/19,68.42%)有2处及2处以上部位受累。结论多数MR患者的PET脑显像存在代谢异常,且病变部位表现为放射性减低区;PET对诊断MR具有一定临床意义。

Objective To observe the cerebral metabolic changes in the patients with mental retardation （MR）. Methods Thirty-two patients with clinically diagnosed MR were examined with ^18 F-FDG PET cerebral imaging, and the distribu- tion change of glucose metabolic in ^18 F-FDG PET cerebral images was observed visually. The relationships of patient＇s low- intelligence quotient with PET, MRI and electroencephalogram （EEG） were analyzed. Results There were 19 patients （19/32, 59.38%） with abnormal PET images among 32 patients. The performance were all hypometabolism without any hypermetabolism, localized in the frontal lobe （6/19, 31.58%）, the temporal lobe （15/19, 78. 95%）, the parietal lobe （12/19, 63.16%） or the occipital lobe and cerebellum （4/19, 21.05%）, respectively. There were 13 patients with 2 or more affected areas （13/19, 68.42%）. Conclusion Abnormal cerebral glucose metabolism could be observed with ^18F- FDG PET in more than half of MR patients, showing as decreased radioactive distribution in the involved areas, implying that PET is useful in the clinical diagnosis of MR.