2009-2011年广州市手足口病病原学分析

Pathogenologic analysis of the Hand-foot-mouth diseases in Guangzhou from 2009 to 2011

目的了解2009-2011年广州市手足口病病例标本中病原学分类情况。方法采集临床诊断为手足口病患者的粪便、咽拭子及肛拭子标本,用荧光定量PCR法同时检测总肠道病毒、CoxA16和EV71。结果广州市手足口病的流行每年有1个高峰和1个次高峰。第1个高峰4～8月的病原体为CoxA16、EV71和其他肠道病毒同时存在,次高峰为11月～次年1月,病原体主要为CoxA16。结论 CoxA16、EV71和其他肠道病毒为广州市近年手足口病的主要病原。

Objective To understand the etiology classification of hand foot and mouth diseases in Guangzhou from 2009 to 2011. Method Collecting the specimens of stool, throat swab and anus swab and detected by fluorescent quantitation PCR. Enterovirus, Coxsackie A16 and EVTlwere detected at the ,rome time. Results There were 2 peaks time of HFMD in Guangzhou. The first peak time was during April to August which caused by Coxsackie A16, Enterovirus 71 and other enterovirus. Coxsackie A16 was the main pathogen of the second peak, the peakr time was form Novbember to January of the next year. Conclusions Coxsackie A16, Entero- virus 71 and the other enterovirus were the main pathogens of HFMD.