CXCL12基因多态性与肿瘤易感性关联的Meta分析

Meta-analysis the association of CXCL12 polymorphism and neoplasms susceptivity

目的运用Meta分析方法综合评价CXCL12 rs1801157基因多态性与肿瘤发病的关系。方法通过计算机检索和手工检索,收集有关CXCL12 rs1801157基因多态性与肿瘤易感性关系的文献,筛选出符合条件的文献,运用Meta分析方法对各项研究进行异质性检验后计算合并OR值及其95%可信区间,并进行敏感性分析及发表偏倚的评估。结果 15篇符合条件的文献纳入本研究,累积病例组3 225例,对照组4 001例。Meta分析合并结果显示突变等位基因A携带者相比野生等位基因G携带者肿瘤发病风险显著提高,合并值OR=1.27 95%CI=1.12～1.43,差异有统计学意义(P<0.01);基因型AA∶GG,GA∶GG和(AA+GA)∶GG合并OR值及其95%可信区间分别是1.30,95%CI=1.05～1.61、1.45,95%CI=1.22～1.72和1.43,95%CI=1.21～1.68,差异均有统计学意义。按肿瘤类型进行分层,A等位基因携带者相比G等位基因携带者显著提高乳腺癌发病(OR=1.32,95%CI=1.15～1.51,P<0.01);AA∶GG,GA∶GG和(AA+GA)∶GG合并OR值及其95%可信区间分别是1.64,95%CI=1.16～2.33、1.42,95%CI=1.18～1.70和1.44,95%CI=1.21～1.72。结论 CXCL12 rs1801157基因多态性与肿瘤易感性有关,突变等位基因A与肿瘤易感性升高有关,基因型AA或基因型GA携带者相对基因型GG携带者肿瘤发病风险提高。突变等位基因A增加乳腺癌易感性。

Objective To analysis the relationship between polymorphism gene of CXCL12 rs1801157 and tumor susceptibility by Meta - analysis. Method Collecting relevant literatures about the association between polymorphism gene of CXCL12rs1801157 and tumor susceptibility under the same criteria by computer retrieval and manual retrieval. Carrying out heterogeneity inspection by Meta - analysis, calculation the OR value and 95% confidence interval, sensitivity and publication bias were evaluated. Results 15 literatures with 3 225 eases and 4 001 controls were included. Onset risk of mutation allele A carrier was obvious higher than wild al- lele gene G carrier, OR = 1.27, 95% CI were 1.12 to 1.43, the difference had statistical significance （P 〈 0. 01） . The OR value and 95%CI of genotype of AA： GG, GA： GG, OR = 1.30, 95% CI = 1.22 - 1.72, （AA ＋ GA） ： GG, OR = 1.43, 95% CI = 1.21 - 1.68. Stratified by tumor types, we found that the breast cancer incidence rate of allele A cartier was higher than allele A cartier G, OR = 1.64, 95% CI = 1.16 - 2. 33. GA：GG, 0R=1.42, 95%CI=1.18 ~I.70. AA＋GA：GG, OR=1.44, 95%CI=1.21-1.72. Condusiom CXCL12rs1801157 polymorphism gene was association with tumor susceptibility. Carriers of genotype AA or GA may association with the high risk of tumor compared with GG genetype. Allele A was a risk factor of breast cancer.