血清肿瘤坏死因子-α与C-反应蛋白水平在慢性阻塞性肺疾病急性加重期的临床意义

Serum Levels of Tumor Necrosis Factor-αand C-reactive Protein in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者血清中TNF-α和CRP水平的变化及其临床意义。方法:比较2010年1月至2011年6月来我院就诊的40例AECOPD患者、40例COPD稳定期患者以及35例健康对照组受试者的血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平,并分析AECOPD患者的血清CRP、TNF-α水平与动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO_2)的相关关系。结果:血清TNF-α和CRP在健康对照组、COPD稳定期组和AECOPD组中的水平依次升高;AECOPD患者的血清TNF-α和CRP水平均与PaO_2呈负相关,而与PaCO_2无相关关系。结论:血清TNF-α、CRP水平可作为AECOPD患者监测病情、评价疗效以及疾病转归的有效指标。

Objective： To investigate the clinical value of serum levels of tumor necrosis factor-α（TNF-α） and C-reactive protein （CRP）in patients with acute exacerbation of chronic obstruction pulmonary disease （AECOPD）. Methods： Serum TNF-α and CRP levels were detected in patients with AECOPD （n=40）,patients with stable COPD （n=40） and reference group（n=35） form Jan 2010 to Jun 2011. Correlations of serum TNF-ot and CRP levels and arterial partial pressure of oxygen （PaO2） and carbon dioxide （PaCO2） were analyzed. Results： Both serum TNF-ot and CRP levels significantly increased in COPD group, especially in AECOPD patients. There was negative correlation between both serum TNF-α and CRP levels and PaO2 but not PaCO2 in patients with AECOPD. Conclusion： Detection of serum TNF-α and CRP levels plays an important role in mornitoring and evaluating therapeutic effect and prognosis of AECOPD.