摘要
目的:研究右美托咪啶对外科重症患者的镇静、镇痛作用。方法:将本院外科重症监护病房需要镇静、镇痛120例患者按照随机原则分为有美托咪啶组(58例)和咪达唑仑组(62例)。右美托咪啶组经静脉泵入负荷剂量1μg·kg^(-1)、10 min,继以0.2~0.7μg·kg^(-1)·h^(-1)维持;咪达唑仑组给予负荷剂量0.06 mg·kg^(-1),再以0.04~0.20 mg·kg^(-1)·h^(-1)维持。结果:右美托咪啶组视觉模拟法(VAS)评分低于咪达唑仑组[(2.38±0.48)分&(6.07±0.79)分,P<0.01];唤醒所需时间显著短于咪达唑仑组[(0.17±0.03)h &(1.63±0.56)h,P<0.01]。右美托咪啶组出现血压下降3例,自主呼吸频率无明显变化;咪达唑仑组出现血压下降10例,出现自主呼吸频率下降3例(P<0.05)。右美托咪啶组中有6例产生顺行性遗忘,咪达唑仑组所有患者均产生顺行性遗忘(P<0.05)。结论:右美托咪啶是外科重症监护病房较为理想的镇静、镇痛药物。
Objective: To investigate the sedative and analgesic effects of dexmedetomidine in patients with serious surgery diseases. Methods: 120 cases admitted to the surgery intensive care unit needed sedation and analgesia were randomly divided into dexmedetomidine group (n =58) and midazolam group (n =62). Dexmedetomidine group received dexmedetomidine as a loading dose of 1 μg/kg for 10 rain followed by a maintenance infusion of (0.2-0.7)μg.kg-1.h-1, when midazolam group received midazolam as a loading dose of 0.06 mg/kg followed by a maintenance infusion of (0.04-0.20)mg. kg-1 h-1 Results: The score of visual analog scale in dexmedetomidine group was lower than that in midazolam group(2.38±0.48 VS. 6.07±0.79,P〈0.01).The awakening time was shorter in dexmedetomidine group than that in midazolam group [(0.17 ±0.03)hours VS. (1.63±0.56)hours,P〈0.01]. Conclusion: Dexmedetomidine is the recommended drug used for sedation and analgesia in surgery intensive care unit.
出处
《岭南急诊医学杂志》
2012年第1期39-40,共2页
Lingnan Journal of Emergency Medicine