依达拉奉治疗老年急性脑梗死临床疗效观察

Clinical Effect on Edaravone on Acute Cerebral Infarction in Aged Patients

目的观察依达拉奉联合疏血通注射液治疗老年急性脑梗死的神经功能评分、临床疗效和不良反应。方法将64例老年急性脑梗死患者随机分为治疗组与对照组,其中治疗组36例、对照组28例。治疗组予以依达拉奉联合疏血通注射液治疗,对照组予以疏血通注射液治疗,疗程为14 d。观察两组患者在治疗前后的临床神经功能缺损程度评分、日常生活活动能力(ADL)评分、临床疗效情况,记录患者不良反应。结果治疗组在治疗后的临床神经功能缺损程度评分、ADL评分较对照组明显降低,差异有统计学意义(P<0.01);治疗组的总有效率为91.7%,对照组为67.9%,差异有统计学意义(P<0.01)。两组患者治疗后均未出现明显不良反应。结论依达拉奉联合疏血通注射液能够促进老年急性脑梗死患者的神经功能康复,减少致残率,提高疗效且安全。

Objective To investigate the clinical effect and adverse reaction of combining Edaravone with Shuxuetong injection in the treatment of acute cerebral infarction（ACI） in old patients. Methods Sixty four old patients with ACI were randomly divided into treatment group（36 cases） and control group（28 cases）. The treatment group received the treatment of combining Edaravone with Shuxuetong injection, while the control group was given Shuxuetong injection. The course of treatment was 14 days. The clinical neural function defect scores, activities of daily living （ADL） scores, the clinical effect and adverse reaction were observed before and after the treatment. Results After the treatment, the neural function defect scores and ADL scores in treatment group was significantly lower than that in control group. The difference of neural function scores between the two groups was significant（ P 〈0.01 ）. The effective rate of treatment group was 91.7% and the control group was 67.9%. The difference of the clinical effect between the two groups was significance（ P 〈 0.01 ）. No obvious adverse reaction was found in two groups. Conclusion Edaravone combined with Shuxuetong injection can promote recovery of nerve function, reduce disability rate, enhance the curative effect and are safety in treatment of old patients with ACI.