摘要
MicroRNA（miRNA）是一类内源性的，长度为21-23个核苷酸的非编码单链小RNA，广泛分布于真核生物中，它们通过调节基因表达和转录后翻译在细胞增生、凋亡，机体生长、发育等方面发挥着广泛而重要的调控作用。miRNA与肝细胞癌的发生发展存在密切关系，部分miRNA充当癌基因或抑癌基因作用。已发现若干miRNA如miR-30d、miR-221、miR-222及miR-101等的异常表达与肝细胞癌的发生发展有关。本文就近年来miRNA与肝细胞癌的相关研究作一总结。
MicroRNA （miRNA） is a class of endogenous, single-stranded non-coding small RNA that contains 21 to 23 nucleotides and is widely distributed in euearyon, miRNA plays an important regulatory role in cell proliferation, apoptosis, growth and development through the regulation of gene translation after transcription and expression, miRNA has a close relationship with pathogenesis and development of hepato- cellular carcinoma. And in this process, part of miRNA acts as oncogenes or tumor suppressor genes. A number of miRNA, such as miR-30d, miR-221, miR-222 and miR-101, had been found to express abnor- mally in hepatocellular carcinoma. Here we summarize the related progress in research of miRNA and hepa- tocellular carcinoma.
出处
《国际外科学杂志》
2012年第7期485-488,共4页
International Journal of Surgery
基金
上海市卫生局青年科研项目（No.201144172）
关键词
癌
肝细胞
微RNAS
癌基因
基因
抑制
Carcinoma, hepatocelluar
MicroRNAs
Oncogenes
Genes, suppressor
