VEGF,MVD在胃癌预后及上消化道出血风险的研究进展

Progress of the Research on the VEGF,MVD in Prognosis,Survival and Risk of Upper Gastrointestinal Hemorrhage in Gastric Cancer

胃癌是危害人类健康的常见恶性肿瘤,也是上消化道出血常见的病因之一。其发生发展是多因素、多基因改变参与的长期、协同的病理过程。血管生成(angiogenesis)是这一发展过程中的关键步骤,血管内皮生长因子(vascular endothelial growth factor,VEGF)和微血管密度(micro vessel density,MVD)作为调控血管生成的主要因子和微血管的主要评价指标,在胃癌患者预后、临床病理因素中的作用被广泛研究。上消化道出血(upper gastrointestinal hemorrhage)是胃癌患者的常见临床症状威胁和影响患者的生存质量。新近有研究者提出,VEGF及MVD与胃癌患者的上消化道出血风险正相关,本文就相关研究进展进行介绍。

Gastric cancer is a common malignant tumor threatening human＇s health and a usual causative disease of upper gastrointestinal hemorrhage. The initiation and development of gastric cancer is a complicated, synergistic, long-term and multi-gene involved pathological process. In this process, angiogenesis plays a major role. Vascular endothelial growth factor （VEGF） and micro vessel density （MVD） are main factors reflecting the angiogenesis and micro vessel generation. And they are extensively studied on the prognosis and clinicalpathology of gastric carcinoma. Meanwhile upper gastrointestinal hemorrhage as a usual symptom of gastric carcinoma threa- tens the life of the sufferers. Recent study showed that VEGF and MVD correlated with the risk of upper gastrointestinal hemorrhage. This paper presents progression of relevant research on VEGF and MVD in prognosis, survival and risk of upper gastrointestinal.