2006～2010年泌尿生殖道炎症患者支原体感染率检测与耐药性分析

Surveillance of mycoplasma infection and drug resistance among urogenital tract infection patients from 2006 to 2010

目的了解杭州市萧山区2006～2010年泌尿生殖道炎症患者支原体感染及耐药情况。方法对4 023例泌尿生殖道炎症患者用支原体鉴定及药敏试剂盒进行支原体培养及药敏试验。结果支原体总检出率为48.1%,女性检出率51.2%明显高于男性41.8%(P<0.05)。支原体培养阳性患者中Uu单独感染1701例(88.0%),Mh单独感染57例(2.9%),Uu+Mh混合感染176例(9.1%),Uu单独感染明显高于Mh单独感染和Uu+Mh混合感染(P<0.05)。5年间支原体阳性检出率从2006年的39.4%到2010年的58.1%逐年增高,感染模式观察期内无明显变化。支原体对交沙霉素、原始霉素和强力霉素均敏感(敏感率≥91.4%),对四环素、红霉素、氧氟沙星和环丙沙星的耐药率高,均大于50%。比较2006年至2010年各种支原体对9种药物的耐药率,除四环素外耐药率呈不同程度上升,四环素耐药率2007年和2008年较高,后逐年下降,2010年为53.5%。混合感染总体耐药率比Uu或Mh单独感染耐药率高。结论泌尿生殖道炎症患者支原体感染Uu比较常见,且女性检出率显著高于男性。临床分离支原体大多具有多重耐药性,临床治疗需根据药敏结果加以选择。

Objective To study the infection and drug resistance of mycoplasma from the urogenital tract samples of STD patients from 2006 to 2010 in Xiaoshan Hangzhou. Method The mycoplasma culture and drug sensitivity test were per-formed by using the mycoplasma detection kits in 4,023 patients with urogenital tract infection from 2006 to 2010. Result A total of 48.1% cases were mycoplasma positive, and the infection rate in feminine （51.2% ） was obviously higher than that in masculine （41.8%） （P 〈 0.05 ）. Among the positive cases, 1,701 （88.0%） were infected with Ureaplasma urealyticum （Uu）, 57 （2.9%） with Mycoplasma hominics （Mh）, and 176 （9.1% ） with both Uu and Mh, with the Uu infection rate being much higher than that of Mh and mixed infection （ P 〈 0.05 ）. The infection rate of Mycoplsma increased from 39.4% in 2006 to 58.1% in 2010, and the infection patterns showed no significant change during five years. The results of drug sensitivity test showed a higher sensitivity to josamyein, pristinamycin and doxycycline （98.9% , 98.3% and 91.4% respectively）. The resistance rates to tetracycline, erythromycin, ofloxaein and ciprofloxacin were all higher than 50%. The resistance rates to all drugs but tetracycline increased yearly. The resistance rate in Uu ＋ Mh infection was higher than that of single infection on the whole. Conclusion The infection of Uu is common in patients wih urogenital tract infection and the infection rate in feminine is higher than that in masculine. Because of multi-drng resistance, antibiotics should be chosen according to drug sensitivi- ty test results.