正交试验法优选头痛滴丸的提取工艺

Optimization of Extraction Process for Toutong Dropping Pill by Orthogonal Test

目的:优选头痛滴丸的醇提工艺。方法:以阿魏酸和木犀草苷提取率为指标,以乙醇体积分数、提取时间、乙醇用量、提取次数为考察因素,采用L9(34)正交试验法优选头痛滴丸的醇提工艺。结果:最佳提取工艺为8倍量60%乙醇回流提取3次,每次2.0 h。结论:该优选工艺合理,稳定可行,有效成分提取率高。

Objective：To optimize ethanol extraction technology of Toutong dropping pill.Method：With yield of ferulic acid and luteoloside as indexes,taking the concentration of ethanol,extraction time,the amount of ethanol and extraction times as factors,ethanol extraction technology of Toutong dropping pill was optimized by L9（34） orthogonal test.Result：Optimal extraction technology was as follows：reflux extracted 3 times with 8 times the amount of 60% ethanol,2 hours every time.Conclusion：This optimized extraction technology was feasible,stable and reasonable with high yield of active ingredients.