大黄对糖尿病肾病患者血脂及TGF-β1水平的影响研究

Effect of rhubarb on lipid and TGF-β1 level in patients with diabetic nephropathy

目的:本临床试验观察大黄对糖尿病肾病患者血脂、TGF-β1的影响情况,以阐明其糖尿病肾病早期诊断的指标,了解大黄治疗DN的作用机制和可能多靶点。方法:选取我院肾病科收治的60例DN患者随机分为3组,分别治疗8周、16周、24周,并观察每个治疗周期的血脂、及血、尿TGF-β1的情况。结果:大黄对DN患者总胆固醇、甘油三酯的影响,16周、24周有统计学意义(P<0.05),大黄对DN患者血TGF-β1的影响结果,16周、24周有统计学意义(P<0.01)。结论:大黄能降低DN患者血脂,说明其对DN患者具有肾脏保护作用。

Objective： To observe the influence of rhubarb on lipid and TGF-β1 level in patients with diabetic nephropathy,to investigate indicators for early diagnosis and to discuss the mechanism of rhubarb in treating diabetic nephropathy（DN） and possibly multi-targets.Methods： A total of 60 DN patients were randomly divided into three groups and were treated for 8 weeks,16 weeks and 24 weeks,respectively.The blood lipids,TGF-β1 in blood and urine during each course were observed.Results： There was significant effect of rhubarb on total cholesterol,triglycerides and serum TGF-β1 in DN patients after 16 weeks and 24 weeks of treatment（P〈0.05）.Conclusions： Rhubarb can reduce blood lipids and the expression of TGF-β1 of patients with DN,and it has renal protective effect.