芙蓉膏外敷治疗腹膜透析导管出口处感染32例

Clinical Effect of External Application of Furong Ointment in Treatment of Peritoneal Dialysis Catheter Exit-Site Infection: A Report of 32 Cases

目的观察芙蓉膏外敷治疗腹膜透析导管出口处感染的临床疗效。方法选取62例腹膜透析导管出口处感染患者,随机分为对照组30例,研究组32例。研究组应用芙蓉膏外敷在隧道口周,对照组应用莫匹罗星软膏外敷隧道口周,两组均每天换药1次,疗程2周。观察治疗前后患者隧道出口处感染情况,采用腹膜透析外出口处评分体系对患者进行评分;同时观察两组1周内感染控制例数和继发腹膜炎例数。结果治疗后两组腹膜透析外出口处评分显著低于治疗前(P<0.01),且研究组评分显著低于对照组(P<0.01)。两组1周内感染控制例数和继发腹膜炎例数比较,差异无统计学意义(P>0.05)。结论芙蓉膏能有效治疗腹膜透析导管出口处感染。

Objective To observe the clinical effect of external application of Furong ointment （containing Folium Hibisci Mutabilis. as the main ingredient） in the treatment of peritoneal dialysis catheter exit-site infection. Methods Sixty-two patients with peritoneal dialysis catheter exit-site infection were randomly divided into control group （n=30） and treatment group （n=32）. The treatment group received therapy with Furong ointment that was externally applied to the exit site, while the control group received therapy with mupirocin ointment that was also externally applied to the exit site. In both groups, dressing change was performed once per day, and each course of treatment was two weeks. An exit-site scoring system was used to evaluate the exit-site infections before and after treatment. The numbers of cases with controlled infection and cases with secondary peritonitis were measured within one week. Results After treatment, both groups showed significantly decreased exit-site scores （P〈0.01）, and the treatment group had significantly lower scores than the control group （P〈0.01）. There were no differences in numbers of cases with controlled in- fection and cases with secondary peritonitis between the two groups （P〉0.05）. Conclusion The peritoneal dialy- sis catheter exit-site infection can be effectively treated with Furong ointment.