复方奥硝唑大黄口腔膜抑菌作用的实验室观察

Anti-bacteria function of compound ornidazole-rhubarb buccal film

目的:观察复方奥硝唑大黄口腔膜的抑菌、缓释和解吸附功能。方法:选择与牙周及龋病相关致病菌,用杯碟法进行复方奥硝唑大黄口腔膜的细菌敏感试验;用附着板法观察抑菌作用及解吸附作用。结果:复方奥硝唑大黄口腔膜对牙龈卟啉单胞菌等菌有明显抑菌作用;对变形链球菌有抗附着作用。结论:复方奥硝唑大黄口腔膜对牙周致病菌有稳定的抑制作用。

OBJECTIVE To observe the antibacterial function of compound ornidazole-rhubarb buccal film（CORBF）, its lo- cal delivery and desorption. METHODS Caries and periodontitis-associated bacteria were chosen. Paper-disc assay was used to test the sensitivity of bacteria to the buccal film, and lamina aflixa assay was applied to analyze the anti bacteria action and des- orpdon of the buccal film. RESULTS Compound ornidazole-rhubarb buccai film had significant anti-bacteria action on P. g and other bacteria. And it could inhibit the absorption of S. mutans. CONCLUSION Compound ornidazole rhubarb buccai film has a stable inhibitory effect on caries and periodontal bacteria.